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CRISPR Activation/Inhibition Experiments Reveal that Expression of Intronic MicroRNA <i>miR-335</i> Depends on the Promoter Activity of its Host Gene <i>Mest</i>

2021-09-15

Abstract excerpt

<h4>ABSTRACT</h4> MicroRNAs are small non-coding RNAs that act as rheostats to modulate gene expression during development, physiology, and disease. Approximately half of mammalian microRNAs are intronic. It is unknown whether intronic miRNA transcription depends on their host gene or a microRNA-specific promoter. Here, we show that CRISPR inhibition of host gene Mest downregulated hosted miR-335 in mouse embry...

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Literature Corpus work
ce016ad3-0845-589f-ab0e-e859b7bb6340
DOI
10.1101/2021.09.15.458166
Open publication

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CRISPR Activation/Inhibition Experiments Reveal that Expression of Intronic MicroRNA <i>miR-335</i> Depends on the Promoter Activity of its Host Gene <i>Mest</i>DOI 10.1101/2021.09.15.458166
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