Article
Targeting human microRNA genes using engineered Tal-effector nucleases (TALENs).
PloS one - 1 Jan 2013
Hu Ruozhen, Wallace Jared, Dahlem Timothy J, Grunwald David Jonah, O'Connell Ryan M
Abstract excerpt
MicroRNAs (miRNAs) have quickly emerged as important regulators of mammalian physiology owing to their precise control over the expression of critical protein coding genes. Despite significant progress in our understanding of how miRNAs function in mice, there remains a fundamental need to be able to target and edit miRNA genes in the human genome. Here, we report a novel approach to disrupting human miRNA genes...
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