Article
MicroRNA cluster 302-367 enhances somatic cell reprogramming by accelerating a mesenchymal-to-epithelial transition.
The Journal of biological chemistry - 13 May 2011
Liao Baojian, Bao Xichen, Liu Longqi, Feng Shipeng, Zovoilis Athanasios, Liu Wenbo, Xue Yanting, Cai Jie, Guo Xiangpeng, Qin Baoming, Zhang Ruosi, Wu Jiayan, Lai Liangxue, Teng Maikun, Niu Liwen, Zhang Biliang, Esteban Miguel A, Pei Duanqing
Abstract excerpt
MicroRNAs (miRNAs) are emerging critical regulators of cell function that frequently reside in clusters throughout the genome. They influence a myriad of cell functions, including the generation of induced pluripotent stem cells, also termed reprogramming. Here, we have successfully delivered entire miRNA clusters into reprogramming fibroblasts using retroviral vectors. This strategy avoids caveats associated...
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