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Article

Activation of Interferon-Stimulated Transcriptomes and ACE2 Isoforms in Human Airway Epithelium Is Curbed by Janus Kinase Inhibitors

2020-12-11

Abstract excerpt

<title>Abstract</title> <p>SARS-CoV-2 infection of human airway epithelium activates genetic programs that lead to progressive hyperinflammation in COVID-19 patients. Here we report on genetic programs activated by interferons and the suppression by Janus kinase (JAK) inhibitors. The angiotensin-converting enzyme 2 (ACE2) is the receptor for SARS-CoV-2 and deciphering its regulation is paramount for understanding...

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Literature Corpus work
cdef93e2-81f7-572c-a9d9-c0db88f48aa9
DOI
10.21203/rs.3.rs-119695/v1
Open publication

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Activation of Interferon-Stimulated Transcriptomes and ACE2 Isoforms in Human Airway Epithelium Is Curbed by Janus Kinase InhibitorsDOI 10.21203/rs.3.rs-119695/v1
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