Article

Interferon-regulated genetic programs and JAK/STAT pathway activate the intronic promoter of the short ACE2 isoform in renal proximal tubules

2021-01-19

Abstract excerpt

<h4>Summary</h4> Recently, a short, interferon-inducible isoform of Angiotensin-Converting Enzyme 2 (ACE2), dACE2 was identified. ACE2 is a SARS-Cov-2 receptor and changes in its renal expression have been linked to several human nephropathies. These changes were never analyzed in context of dACE2 , as its expression was not investigated in the kidney. We used Human Primary Proximal Tubule (HPPT) cells to show g...

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Literature Corpus work: f1de26e8-7eae-5774-bea2-6ce14f85432b
DOI: 10.1101/2021.01.15.426908

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Interferon-regulated genetic programs and JAK/STAT pathway activate the intronic promoter of the short ACE2 isoform in renal proximal tubulesDOI 10.1101/2021.01.15.426908Read

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