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Transcriptional autoregulation by <i>Mycobacterium tuberculosis</i> PhoP involves recognition of novel direct repeat sequences in the regulatory region of the promoter

12 Sept 2006

Abstract excerpt

The PhoP-PhoR two-component system is essential for virulence and intracellular growth of Mycobacterium tuberculosis (MTB) in human and mouse macrophages or in mice. Here, PhoP and truncated PhoR sensor proteins were shown to participate in phosphotransfer reactions using conserved residues characteristic of two-component signaling systems. beta-Galactosidase activity originating from phoP promoter-lacZ construct...

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Identifiers

PMID: 16979633
DOI: 10.1016/j.febslet.2006.09.004

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