Article

Spatial patterns of APOBEC mutagenesis in the tumour microenvironment of Asian breast cancer

2026-01-02

Abstract excerpt

A germline deletion of the coding region at the APOBEC3B ( A3B ) gene that is common in Asian and Oceanic populations has been found to be correlated with increased APOBEC mutagenesis, immune activation, and tumour heterogeneity in breast cancer. The mechanism by which A3B deletion and APOBEC mutagenesis induces immune activation in Asian breast cancers is still unclear, but has been thought to involve increase...

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Literature Corpus work: cdd02dc5-4cdd-51c5-ad4d-fb7d32efd42c
DOI: 10.64898/2026.01.01.697328

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