Back to search

Article

Germline <i>APOBEC3B</i> deletion in Asian women increases somatic hypermutation in breast cancer that is associated with Her2 subtype, <i>PIK3CA</i> mutations, immune activation, and increased survival

2020-06-05

Abstract excerpt

A 30-kb deletion that eliminates the coding region of APOBEC3B ( A3B ) is >5 times more common in women of Asian compared to European descent. This polymorphism creates a chimera with the APOBEC3A ( A3A ) coding region and A3B 3’UTR, and is associated with an increased risk for breast cancer in Asian women. Here, we explored the relationship between the A3B deletion polymorphism with tumour characteristics i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
b0855d6e-3ba9-5150-8fd5-1e13dac7e227
DOI
10.1101/2020.06.04.135251
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Germline <i>APOBEC3B</i> deletion in Asian women increases somatic hypermutation in breast cancer that is associated with Her2 subtype, <i>PIK3CA</i> mutations, immune activation, and increased survivalDOI 10.1101/2020.06.04.135251
Germline APOBEC3B deletion increases somatic hypermutation in Asian breast cancer that is associated with Her2 subtype, PIK3CA mutations and immune activationSemantic proximity
Integrative genomic analyses of APOBEC-mutational signature, expression and germline deletion of APOBEC3 genes, and immunogenicity in multiple cancer typesSemantic proximity
<i>APOBEC3B</i> expression in breast cancer reflects cellular proliferation, while a deletion polymorphism is associated with immune activationSemantic proximity
Germline APOBEC3B deletion is associated with breast cancer risk in an Asian multi-ethnic cohort and with immune cell presentation.Semantic proximity
APOBEC3 deletion increases the risk of breast cancer: a meta-analysis.Semantic proximity
Pembrolizumab monotherapy for previously treated metastatic HER2-negative breast cancer with germline<i>APOBEC3B</i>deletion: results of the phase II AUROR studySemantic proximity
APOBEC in breast cancer: a dual player in tumor evolution and therapeutic responseSemantic proximity
APOBEC3B is an enzymatic source of mutation in breast cancer.Semantic proximity
APOBEC3A is a prominent cytidine deaminase in breast cancer.Semantic proximity
Spatial patterns of APOBEC mutagenesis in the tumour microenvironment of Asian breast cancerSemantic proximity
Identifying germline APOBEC3B deletion and immune phenotype in Korean patients with operable breast cancer.Semantic proximity
Characterization of the somatic landscape and transcriptional profile of breast tumors from 748 Hispanic/Latina women in CaliforniaSemantic proximity
Select a neighboring publication to make it the new centre.