Article

APOBEC3-driven neoantigen-rich cancers co-opt 1q23.3 amplification for tumor-intrinsic immune cloaking

2026-07-04

Abstract excerpt

Hypermutational processes, including those driven by the APOBEC3 family of cytidine deaminases, generate abundant neoantigens yet give rise to tumors that evade immune recognition. Here, using multi-omics analyses followed by functional validation, we identified a tumor-intrinsic immune-cloaking mechanism in neoantigen-rich epithelial cancers, characterized by coordinated suppression of antigen presentation, immun...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 89b2743f-b74e-52b0-9e3e-c3f07e1fb645
DOI: 10.64898/2026.07.01.735125

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

APOBEC3-driven neoantigen-rich cancers co-opt 1q23.3 amplification for tumor-intrinsic immune cloakingDOI 10.64898/2026.07.01.735125Read

APOBEC3G expression marks a TMB-high, T cell-inflamed tumor state and is associated with response to immune checkpoint blockade in multiple cancer cohortsSemantic proximity Read

Neoantigen-specific immunity in low mutation burden colorectal cancers of the consensus molecular subtype 4.Semantic proximity Read

A functional identification platform reveals frequent, spontaneous neoantigen-specific T cell responses in patients with cancerSemantic proximity Read

Tumour-wide RNA splicing aberrations generate actionable public neoantigensSemantic proximity Read

Identification and characterization of neoantigen-reactive CD8+ T cells following checkpoint blockade therapy in a pan-cancer settingSemantic proximity Read

Cancer neoantigens as potential targets for immunotherapy.Semantic proximity Read

Integrated modeling to implicate evolving neoantigen-T cell interplays and immunotherapy efficacy in tumorsSemantic proximity Read

Indication-specific tumor evolution and its impact on neoantigen targeting and biomarkers for individualized cancer immunotherapiesSemantic proximity Read

Multi-omics sequencing of gastroesophageal junction adenocarcinoma reveals prognosis-relevant key factors and a novel immunogenomic classification.Semantic proximity Read

INAEME: Integral Neoantigen Analysis with Entirety of Mutational EventsSemantic proximity Read

Recurrent Neoantigens in Colorectal Cancer as Potential Immunotherapy TargetsSemantic proximity Read

In silico neoantigen screening and HLA multimer-based validation identify immunogenic neopeptide in multifocal lung adenocarcinoma.Semantic proximity Read