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Article

Germline APOBEC3B deletion is associated with breast cancer risk in an Asian multi-ethnic cohort and with immune cell presentation.

Breast cancer research : BCR - 27 May 2016

Wen Wei Xiong, Soo Jaslyn Sian-Siu, Kwan Pui Yoke, Hong Elaine, Khang Tsung Fei, Mariapun Shivaani, Lee Christine Shu-Mei, Hasan Siti Norhidayu, Rajadurai Pathmanathan, Yip Cheng Har, Mohd Taib Nur Aishah, Teo Soo Hwang

Abstract excerpt

BACKGROUND: APOBEC3B is a cytosine deaminase implicated in immune response to viral infection, cancer predisposition and carcinogenesis. Germline APOBEC3B deletion is more common in East Asian women and confers a modest risk to breast cancer in both East Asian and Caucasian women. Analysis of tumour samples from women of European descent has shown that germline APOBEC3B deletion is associated with an increased...

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Identifiers

PMID: 27233495
DOI: 10.1186/s13058-016-0717-1
PMCID: PMC4884363

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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