Article

A Long-lived Avatar for Modeling Age-Related Vascular Disease

2026-05-04

Abstract excerpt

<h4>Background</h4> Current microphysiological models do not support long-term investigations into the chronic effects of vascular risk factors and the development of vascular diseases. Prolonged culture frequently leads to cellular senescence and loss of functional integrity, resulting in variability and inconsistency in modeling chronic vascular responses. Here we aimed to develop and sustain a long-term multic...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cdb9f1c4-90a4-5fcf-bc92-b3bdaaeeef8e
DOI: 10.64898/2026.04.29.721776

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A Long-lived Avatar for Modeling Age-Related Vascular DiseaseDOI 10.64898/2026.04.29.721776Read

Bioengineered iPSC Vessels Recapitulate Human Vascular Physiological Function and Aging PhenotypesSemantic proximity Read

Vascular organoid model of Hutchinson-Gilford progeria syndrome uncovers repression of the SRF pathway in premature aging.Semantic proximity Read

A Tissue Engineered Blood Vessel Model of Hutchinson-Gilford Progeria Syndrome Using Human iPSC-derived Smooth Muscle Cells.Semantic proximity Read

Harnessing iPSCs, 3D organoids, and multiomics to model rare vascular diseases: Emerging new approach methodologies.Semantic proximity Read

iPSC-Derived Endothelial Cells Affect Vascular Function in a Tissue-Engineered Blood Vessel Model of Hutchinson-Gilford Progeria Syndrome.Semantic proximity Read

Recent Advances and Future Perspectives in Vascular Organoids and Vessel-on-ChipSemantic proximity Read

Model Systems to Study the Mechanism of Vascular AgingSemantic proximity Read

Artery-on-chip demonstrates smooth muscle function comparable to both healthy and diseased living tissuesSemantic proximity Read

Identification of cellular heterogeneity and key signaling pathways associated with vascular remodeling and calcification in young and old primate aortas based on single-cell analysisSemantic proximity Read

Human vascular organoids with a mosaic <i>AKT1</i> mutation recapitulate Proteus syndromeSemantic proximity Read

Applications, challenges, and prospects of induced pluripotent stem cells for vascular diseaseSemantic proximity Read

A Microphysiological HHT-on-a-Chip Platform Recapitulates Patient Vascular LesionsSemantic proximity Read