Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Tissue Engineered Blood Vessel Model of Hutchinson-Gilford Progeria Syndrome Using Human iPSC-derived Smooth Muscle Cells.

Scientific reports - 15 Aug 2017

Atchison Leigh, Zhang Haoyue, Cao Kan, Truskey George A

Abstract excerpt

Hutchison-Gilford Progeria Syndrome (HGPS) is a rare, accelerated aging disorder caused by nuclear accumulation of progerin, an altered form of the Lamin A gene. The primary cause of death is cardiovascular disease at about 14 years. Loss and dysfunction of smooth muscle cells (SMCs) in the vasculature may cause defects associated with HGPS. Due to limitations of 2D cell culture and mouse models, there is a need...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Vessels
Share to Everolimus
Share to Induced Pluripotent Stem Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lamin Type A

Share to Myocytes, Smooth Muscle

Share to Progeria

Share to Sirolimus

Share to Tissue Engineering

Source

Open in PubMed Open full text

Identifiers

PMID: 28811655
DOI: 10.1038/s41598-017-08632-4
PMCID: PMC5557922

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Tissue Engineered Blood Vessel Model of Hutchinson-Gilford Progeria Syndrome Using Human iPSC-derived Smooth Muscle Cells.PMID 28811655Read ↗

iPSC-Derived Endothelial Cells Affect Vascular Function in a Tissue-Engineered Blood Vessel Model of Hutchinson-Gilford Progeria Syndrome.Semantic proximity Read ↗

Molecular and Cellular Mechanisms Driving Cardiovascular Disease in Hutchinson-Gilford Progeria Syndrome: Lessons Learned from Animal Models.Semantic proximity Read ↗

A Long-lived Avatar for Modeling Age-Related Vascular DiseaseSemantic proximity Read ↗

Artery-on-chip demonstrates smooth muscle function comparable to both healthy and diseased living tissuesSemantic proximity Read ↗

Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome.Semantic proximity Read ↗

Applications, challenges, and prospects of induced pluripotent stem cells for vascular diseaseSemantic proximity Read ↗

Modeling and rescue of the vascular phenotype of Williams-Beuren syndrome in patient induced pluripotent stem cells.Semantic proximity Read ↗

Differentiation of human induced-pluripotent stem cells into smooth muscle cellsSemantic proximity Read ↗

Harnessing iPSCs, 3D organoids, and multiomics to model rare vascular diseases: Emerging new approach methodologies.Semantic proximity Read ↗

Telomerase therapy reverses vascular senescence and extends lifespan in progeria miceSemantic proximity Read ↗

Vascular organoid model of Hutchinson-Gilford progeria syndrome uncovers repression of the SRF pathway in premature aging.Semantic proximity Read ↗

Engineering vascular tissue with functional smooth muscle cells derived from human iPS cells and nanofibrous scaffolds.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.