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Article

A Safeguard System for Induced Pluripotent Stem Cell-Derived Rejuvenated T Cell Therapy

29 Aug 2015

Abstract excerpt

The discovery of induced pluripotent stem cells (iPSCs) has created promising new avenues for therapies in regenerative medicine. However, the tumorigenic potential of undifferentiated iPSCs is a major safety concern for clinical translation. To address this issue, we demonstrated the efficacy of suicide gene therapy by introducing inducible caspase-9 (iC9) into iPSCs. Activation of iC9 with a specific chemical...

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PMID: 26321144
DOI: 10.1016/j.stemcr.2015.07.011

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