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Article

ALDH1A1 in breast cancer: A prospective target to overcome therapy resistance (Review)

4 Mar 2025

Abstract excerpt

The expression of cytosolic aldehyde dehydrogenases (ALDHs), which mediate the last step in the pathway of the synthesis of all-trans retinoic acid, is dysregulated in various types of human cancer, and has been associated with the development of cancer stem cells (CSCs) in solid tumors and hematological malignancies. CSCs are considered a minor fraction of cancer cells with the capacity to initiate neoplastic...

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PMID: 40093866
DOI: 10.3892/ol.2025.14959

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