Article

TRAF1 S146 is constitutively phosphorylated in primary CLL cells by PKN1/2

2026-02-17

Abstract excerpt

TRAF1 is a pro-survival signaling adaptor that contributes to NF-κB activation downstream of a subset of TNFR superfamily members. TRAF1 is overexpressed in many cancers of mature B cells, including chronic lymphocytic leukemia (CLL). Previous studies have established that TRAF1 S146 is a target of phosphorylation by the kinase PKN1 and that PKN1 is required to prevent cellular inhibitor of apoptosis protein (cIAP...

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Literature Corpus work: cd822185-0d25-5f51-ad5c-57b20f86ac8b
DOI: 10.64898/2026.02.11.26346036

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