Article
Mutations which abolish phosphorylation of the TRAF-binding domain of TNF receptor 2 enhance receptor-mediated NF-kappa B activation.
Biochemical and biophysical research communications - 27 Mar 1998
Ng P W, Jänicke R U, Porter A G
Abstract excerpt
We demonstrate that a 41 amino acid region (amino acids 379 to 419) in the cytoplasmic domain of tumor necrosis factor receptor 2 (TNFR2) is phosphorylated by unidentified kinase(s) both in vitro and in vivo. This domain (denoted x1c) corresponds almost exactly to the previously identified TRAF-b...
Topics
- Amino Acid Sequence
- Antigens, CD
- Binding Sites
- Gene Expression
- Genes, Reporter
- Molecular Sequence Data
- Mutation
- NF-kappa B
- Peptide Mapping
- Phosphorylation
- Protein Serine-Threonine Kinases
- Receptors, Tumor Necrosis Factor
- Receptors, Tumor Necrosis Factor, Type II
- Recombinant Proteins
- Signal Transduction