Article

Separating the signal from the noise in metagenomic cell-free DNA sequencing

2019-08-13

Abstract excerpt

<h4>ABSTRACT</h4> Cell-free DNA (cfDNA) in blood, urine and other biofluids provides a unique window into human health. A proportion of cfDNA is derived from bacteria and viruses, creating opportunities for the diagnosis of infection via metagenomic sequencing. The total biomass of microbial-derived cfDNA in clinical isolates is low, which makes metagenomic cfDNA sequencing susceptible to contamination and alignm...

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Literature Corpus work: cd39a8a6-5cd0-5832-bb61-7017acefd843
DOI: 10.1101/734756

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