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Detection of cell-free microbial DNA using a contaminant-controlled analysis framework

23 Jun 2021

Abstract excerpt

BACKGROUND: The human microbiome plays an important role in cancer. Accumulating evidence indicates that commensal microbiome-derived DNA may be represented in minute quantities in the cell-free DNA of human blood and could possibly be harnessed as a new cancer biomarker. However, there has been limited use of rigorous experimental controls to account for contamination, which invariably affects low-biomass...

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PMID: 34162397
DOI: 10.1186/s13059-021-02401-3

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