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Separating the signal from the noise in metagenomic cell-free DNA sequencing

11 Feb 2020

Abstract excerpt

BACKGROUND: Cell-free DNA (cfDNA) in blood, urine, and other biofluids provides a unique window into human health. A proportion of cfDNA is derived from bacteria and viruses, creating opportunities for the diagnosis of infection via metagenomic sequencing. The total biomass of microbial-derived cfDNA in clinical isolates is low, which makes metagenomic cfDNA sequencing susceptible to contamination and alignment...

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PMID: 32046792
DOI: 10.1186/s40168-020-0793-4

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