Article

GCfix: A Fast and Accurate Fragment Length-Specific Method for Correcting GC Bias in Cell-Free DNA

2024-11-08

Abstract excerpt

<h4>Motivation</h4> Cell-free DNA (cfDNA) analysis has wide-ranging clinical applications due to its non-invasive nature. However, cfDNA fragmentomics and copy number analysis can be complicated by GC bias. There is a lack of GC correction software based on rigorous cfDNA GC bias analysis. Furthermore, there is no standardized metric for comparing GC bias correction methods across large sample sets, nor a rigorou...

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Literature Corpus work: 6a17c52e-6e15-54c2-8c3d-334a4ca64300
DOI: 10.1101/2024.11.07.622399

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