Article

Local immunoglobulin expression in myositis is associated with interferon gamma signaling and correlates with disease activity

2025-06-04

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objectives</h4> Autoantibodies may play a role in the pathogenesis of myositis and are locally produced within muscle tissue. This study aimed to characterize the local expression of immunoglobulin genes across different subgroups of myositis, identify pathways associated with this expression, and evaluate correlations with disease activity. <h4>Methods</h4> Bulk RNA sequencing was performed...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ccfe1707-6181-5b7b-9aa7-440128d52123
DOI: 10.1101/2025.06.03.25328909

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Local immunoglobulin expression in myositis is associated with interferon gamma signaling and correlates with disease activityDOI 10.1101/2025.06.03.25328909Read

Identification of distinctive interferon gene signatures in different types of myositisSemantic proximity Read

Transcriptomic profiling reveals distinct subsets of immune checkpoint inhibitor-induced myositisSemantic proximity Read

Distinct Cytokine and Cytokine Receptor Expression Patterns Characterize Different Forms of MyositisSemantic proximity Read

Molecular profiles of inflammatory myopathiesSemantic proximity Read

Transcriptome Profiling of Immune Cell Types in Peripheral Blood Reveals Common and Specific Pathways Involved in the Pathogenesis of Myositis‐Specific Antibody‐Positive Inflammatory MyopathiesSemantic proximity Read

High-Resolution Spatial Transcriptomics Reveals Interferon-Associated Immune Niches and Antigen Presentation Programs in Inclusion Body MyositisSemantic proximity Read

Type I interferon–inducible gene expression in blood is present and reflects disease activity in dermatomyositis and polymyositisSemantic proximity Read

Type 1 interferon signature in peripheral blood mononuclear cells and monocytes of idiopathic inflammatory myopathy patients with different myositis-specific autoantibodiesSemantic proximity Read

Pathogenic autoantibody internalization in myositisSemantic proximity Read

Classification of myositis.Semantic proximity Read

Identification of a distinctive gene signature in granulomatous myositisSemantic proximity Read

Lupus myositis, a type I interferon driven necrotizing myopathy with regional heterogeneitySemantic proximity Read