Article

High-Resolution Spatial Transcriptomics Reveals Interferon-Associated Immune Niches and Antigen Presentation Programs in Inclusion Body Myositis

2026-08-25

Abstract excerpt

Inclusion body myositis (IBM) is a progressive inflammatory myopathy characterized by muscle fiber degeneration, immune infiltration, and protein aggregation. Despite the prominent immune infiltrates that characterizes IBM muscle, the factors driving immune infiltration remain unknown, and the repertoire and spatial organization of infiltrating immune populations remain poorly defined. Here, we used high-resolutio...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9edea2f2-3821-58d7-bac3-5370f835f381
DOI: 10.64898/2026.08.23.26361142

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

High-Resolution Spatial Transcriptomics Reveals Interferon-Associated Immune Niches and Antigen Presentation Programs in Inclusion Body MyositisDOI 10.64898/2026.08.23.26361142Read

Cell type mapping of inflammatory muscle diseases highlights selective myofiber vulnerability in inclusion body myositisSemantic proximity Read

Local immunoglobulin expression in myositis is associated with interferon gamma signaling and correlates with disease activitySemantic proximity Read

Immune and myodegenerative pathomechanisms in inclusion body myositisSemantic proximity Read

Identification of a distinctive gene signature in granulomatous myositisSemantic proximity Read

Molecular profiles of inflammatory myopathiesSemantic proximity Read

Distinct Cytokine and Cytokine Receptor Expression Patterns Characterize Different Forms of MyositisSemantic proximity Read

Transcriptomic profiling reveals distinct subsets of immune checkpoint inhibitor-induced myositisSemantic proximity Read

Lupus myositis, a type I interferon driven necrotizing myopathy with regional heterogeneitySemantic proximity Read

Sporadic inclusion body myositis-derived myotube culture revealed muscle cell-autonomous expression profilesSemantic proximity Read

Antigen-driven T cell-macrophage interactions mediate the interface between innate and adaptive immunity in histidyl-tRNA synthetase-induced myositisSemantic proximity Read

Transcriptional profiling identifies differential expression of long non-coding RNAs in Jo-1 associated and inclusion body myositisSemantic proximity Read

Identification of distinctive interferon gene signatures in different types of myositisSemantic proximity Read