Article

Identification of a distinctive gene signature in granulomatous myositis

2025-01-02

Abstract excerpt

<h4>SUMMARY</h4> <h4>Objectives</h4> Granulomatous myositis (GM) is defined by focal collections of activated macrophages that fuse to form multinucleated cells that aggregate into granulomas within skeletal muscle. This study aimed to elucidate the pathophysiology of GM by defining its specific transcriptomic profile. <h4>Methods</h4> Bulk RNA sequencing was performed on 722 muscle biopsies, including 38 from pat...

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Literature Corpus work: fa82b80c-edb5-5e04-a839-339a531a0fc0
DOI: 10.1101/2024.12.27.24319708

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