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Single synapse indicators of impaired glutamate clearance derived from fast iGlu <i> <sub>u</sub> </i> imaging of cortical afferents in the striatum of normal and Huntington (Q175) mice

2018-10-29

Abstract excerpt

<h4>ABSTRACT</h4> Changes in the balance between glutamate (Glu) release and uptake may stimulate synaptic reorganization and even synapse loss. In the case of neurodegeneration, a mismatch between astroglial Glu uptake and presynaptic Glu release could be detected if both parameters were assessed independently and at a single synapse level. This has now become possible due to a new imaging assay with the genetic...

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Literature Corpus work
ccf23a4d-dd9e-557a-8bcd-79f91ed70b3a
DOI
10.1101/455758
Open publication

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