Article

Multi-Omics Panoramic Analysis of HBV Integration, Transcriptional Regulation, and Epigenetic Modifications in PLC/PRF/5 Cell Line

2024-04-23

Abstract excerpt

<h4>Background: </h4> The clearance or transcriptional silencing of integrated HBV DNA is crucial for achieving a functional cure in patients with chronic hepatitis B (CHB) and reducing the risk of hepatocellular carcinoma (HCC) development. The PLC/PRF/5 cell line is commonly used as an in vitro model for studying HBV integration. In this study, we employed a range of multi-omics techniques to gain a panoramic...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cce6ebd9-40a0-5831-942e-cf1720aa5898
DOI: 10.22541/au.169683861.12862176/v3

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Multi-Omics Panoramic Analysis of HBV Integration, Transcriptional Regulation, and Epigenetic Modifications in PLC/PRF/5 Cell LineDOI 10.22541/au.169683861.12862176/v3Read

Analysis of HBV Genomes Integrated into the Genomes of Human Hepatoma PLC/PRF/5 Cells by HBV Sequence Capture-Based Next-Generation SequencingSemantic proximity Read

Recurrent Targeted Genes of Hepatitis B Virus in the Liver Cancer Genomes Identified by a Next-Generation Sequencing–Based ApproachSemantic proximity Read

Three-dimensional and single-cell sequencing of liver cancer reveals comprehensive host-virus interactions in HBV infectionSemantic proximity Read

Insights into Hepatitis B Virus DNA Integration-55 Years after Virus DiscoverySemantic proximity Read

Integrated analysis of whole genome and transcriptome sequencing reveals diverse transcriptomic aberrations driven by somatic genomic changes in liver cancers.Semantic proximity Read

HBV integrations reshaping genomic structures promote hepatocellular carcinomaSemantic proximity Read

The effects of hepatitis B virus integration into the genomes of hepatocellular carcinoma patients.Semantic proximity Read

Analysis of viral integration reveals new insights of oncogenic mechanism in HBV infected- intrahepatic cholangiocarcinoma and combined hepatocellular-cholangiocarcinomaSemantic proximity Read

Long read sequencing reveals sequential complex rearrangements driven by Hepatitis B virus integrationSemantic proximity Read

HBV Genomic Integration and Hepatocellular CarcinomaSemantic proximity Read

Characteristics of Hepatitis B virus integration and mechanism of inducing chromosome translocationSemantic proximity Read

Cellular Genomic Sites of Hepatitis B Virus DNA IntegrationSemantic proximity Read