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Article

Predicting Mutation-Disease Associations Through Protein Interactions Via Deep Learning.

IEEE journal of biomedical and health informatics - 1 Jun 2025

Li Xue, Cao Ben, Wang Jianmin, Meng Xiangyu, Wang Shuang, Huang Yu, Petretto Enrico, Song Tao

Abstract excerpt

Disease is one of the primary factors affecting life activities, with complex etiologies often influenced by gene expression and mutation. Currently, wet lab experiments have analyzed the mechanisms of mutations, but these are usually limited by the costs of wet experiments and constraints in sample types and scales. Therefore, this paper constructs a real-world mutation-induced disease dataset and proposes...

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Identifiers

PMID: 40031830
DOI: 10.1109/JBHI.2025.3541848

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