Article

Expansion of triplet nucleotide repeats in primates and other vertebrates: an evolutionary perspective

2023-04-06

Abstract excerpt

<h4>ABSTRACT</h4> Triplet nucleotide repeat (TNR) expansion has been linked to more than 40 inheritable neurological, neuromuscular and neurodegenerative disorders. Increase in copy number beyond a threshold causes further rapid expansion of the repeats, leading to instability and disease via gain/loss of function, toxic RNA products or chromosome instability. An analysis of these repeat regions across vertebrate...

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Literature Corpus work: ccddecc8-981a-5fc4-a4e2-a514466b5a42
DOI: 10.1101/2023.04.05.535742

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