Trinucleotide repeat expansion and neuropsychiatric disease.

Abstract excerpt

Trinucleotide, or triplet, repeats consist of 3 nucleotides consecutively repeated (e.g., CCG CCG CCG CCG CCG) within a region of DNA, a not uncommon motif in the genome of humans and other species. In 1991, a new type of genetic mutation was discovered, known as a dynamic or expansion mutation, in which the number of triplets in a repeat increases and the length becomes unstable. During the past decade, nearly...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Autistic Disorder
• Share to Bipolar Disorder
• Share to Fragile X Syndrome