Triplet repeat length bias and variation in the human transcriptome.

doi:10.1073/pnas.0907112106

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Article

Triplet repeat length bias and variation in the human transcriptome.

Proceedings of the National Academy of Sciences of the United States of America - 6 Oct 2009

Molla Michael, Delcher Arthur, Sunyaev Shamil, Cantor Charles, Kasif Simon

Abstract excerpt

Length variation in short tandem repeats (STRs) is an important family of DNA polymorphisms with numerous applications in genetics, medicine, forensics, and evolutionary analysis. Several major diseases have been associated with length variation of trinucleotide (triplet) repeats including Huntington's disease, hereditary ataxias and spinobulbar muscular atrophy. Using the reference human genome, we have...

Topics

Animals
Base Sequence
Databases, Nucleic Acid
Gene Expression Profiling
Gene Frequency
Genetic Predisposition to Disease
Genetic Variation
Genome, Human
Humans
Microsatellite Repeats
Pan troglodytes
Polymorphism, Genetic
Trinucleotide Repeat Expansion
Trinucleotide Repeats

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Identifiers

PMID: 19805156
DOI: 10.1073/pnas.0907112106
PMCID: PMC2746125

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