Genes with triplet repeats: a new class of mutations causing neurological diseases.

Abstract excerpt

Microsatellites, simple tamdem repeats of 2 to 4 nucleotide sequences, are widely distributed throughout the genome. Trinucleotide repeats are found every 300 to 500 kb. Recently, a new type of mutation was described involving a specific expansion of triplets within or in close proximity to a gene. Expanded triplets have been found in the genes causing six different neurological disorders: fragile X syndrome...

Topics

• DNA
• Female
• Fragile X Syndrome
• Humans
• Huntington Disease
• Male
• Muscular Atrophy, Spinal
• Mutation
• Myotonic Dystrophy
• Nervous System Diseases
• Repetitive Sequences, Nucleic Acid