Tandem repeats in human brain evolution and disease susceptibility.

Abstract excerpt

Tandem repeats (TRs) are dynamic genomic elements characterized by exceptionally high mutation rates, reversibility, and the capacity to generate graduated phenotypic effects. These properties enable TRs to modulate gene regulation at multiple levels-from transcription and chromatin organization to splicing and protein function. In the human lineage, TR expansions have been recurrently associated with brain...

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