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Article

Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes.

The Journal of biological chemistry - 19 Feb 2016

Laukka Tuomas, Mariani Christopher J, Ihantola Tuukka, Cao John Z, Hokkanen Juho, Kaelin William G, Godley Lucy A, Koivunen Peppi

Abstract excerpt

The TET enzymes are members of the 2-oxoglutarate-dependent dioxygenase family and comprise three isoenzymes in humans: TETs 1-3. These TETs convert 5-methylcytosine to 5-hydroxymethylcytosine (5-hmC) in DNA, and high 5-hmC levels are associated with active transcription. The importance of the balance in these modified cytosines is emphasized by the fact that TET2 is mutated in several human cancers, including...

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Source

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Identifiers

PMID: 26703470
DOI: 10.1074/jbc.M115.688762
PMCID: PMC4759199

Genes

TET1
TET2
TET3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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