Article

The transaminase-ω-amidase pathway is a redox switch in glutamine metabolism that generates α-ketoglutarate

2024-08-29

Abstract excerpt

<h4>Summary</h4> Oxidative stress is caused by short-lived molecules and metabolic changes belong to the fastest cellular responses. Here we studied how the endothelial cell metabolome reacts to acute oxidative challenges (menadione or H 2 O 2 ) to identify redox-sensitive metabolic enzymes. H 2 O 2 selectively increased α-ketoglutara ma te (αKGM), a largely uncharacterized metabolite produced by glutamine t...

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Literature Corpus work: 56b7f45f-146c-5558-a242-0d29b250ffd8
DOI: 10.1101/2024.08.28.610061

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