Article

Molecular Imaging with Fibroblast Activation Protein Tracers depicts Inflammatory Joint Damage and its Transition to Resolution of Inflammation

2023-01-19

Abstract excerpt

<h4>ABSTRACT</h4> Joint fibroblasts play an important role in the transition from joint inflammation to irreversible joint damage. There is no established clinical method to measure fibroblast activation during inflammation and their phenotypic dynamics upon therapy to date. Here we show that upon treatment with IL-17A/TNF-blocking antibodies fibroblasts change their phenotype from a destructive IL-6 + /MMP3 +...

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Literature Corpus work: cc79bb4c-148e-514a-a7bf-b745a5f291ce
DOI: 10.1101/2023.01.17.524425

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