Induction of TGF‐β receptor I expression in a DNA methylation‐independent manner mediated by DNMT3A downregulation is involved in early‐onset severe preeclampsia

Abstract excerpt

Preeclampsia, especially early-onset severe preeclampsia is one of the leading causes of maternal and fetal morbidity and mortality. Although it has been well known that the pathophysiology of early-onset severe preeclampsia begins with abnormal placentation and aberrant activation of TGF-β signaling inhibits trophoblast cell invasion, the mechanisms underlying dysregulation of TGF-β signaling in early-onset...

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