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HSD17B1-mediated trophoblast differentiation lowers estrogen levels in early-onset preeclampsia

20 May 2025

Abstract excerpt

Early-onset preeclampsia (EOPE) with fetal growth restriction (FGR) is a severe hypertensive disorder of pregnancy characterized by placental dysfunction and estrogen deficiency. Based on single-cell RNA sequencing (scRNA-seq) profiling of specific placental trophoblast subtypes from EOPE-FGR and normotensive pregnancies, we identified HSD17B1, which encodes a key enzyme mediating estradiol conversion, as the...

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PMID: 40394177
DOI: 10.1038/s41598-025-02490-1

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