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Slc35a2 mosaic knockout impacts cortical development, dendritic arborisation, and neuronal firing

3 Sept 2024

Abstract excerpt

Mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy (MOGHE) is an important cause of drug-resistant epilepsy. A significant subset of individuals diagnosed with MOGHE display somatic mosaicism for loss-of-function variants in SLC35A2, which encodes the UDP-galactose transporter. We developed a mouse model to investigate how disruption of this transporter leads to a malformation...

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PMID: 39236911
DOI: 10.1016/j.nbd.2024.106657

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