Article
Fibroblast growth factor 21 is a hepatokine involved in MASLD progression.
United European gastroenterology journal - 1 Oct 2024
Gallego-Durán Rocío, Ampuero Javier, Maya-Miles Douglas, Pastor-Ramírez Helena, Montero-Vallejo Rocío, Rivera-Esteban Jesús, Álvarez-Amor Leticia, Pareja María Jesús, Rico María Carmen, Millán Raquel, Robles-Frías María José, Aller Rocío, Rojas Ángela, Muñoz-Hernández Rocío, Gil-Gómez Antonio, Gato Sheila, García-Lozano María, Arias-Loste María Teresa, Abad Javier, Calleja José Luis, Andrade Raúl J, Crespo Javier, González-Rodríguez Águeda, García-Monzón Carmelo, Andreola Fausto, Pericás Juan Manuel, Jalan Rajiv, Martín-Bermudo Francisco, Romero-Gómez Manuel
Abstract excerpt
AIM: We aimed to assess the role of FGF21 in metabolic dysfunction-associated steatotic liver disease (MASLD) at a multi-scale level. METHODS: We used human MASLD pathology samples for FGF21 gene expression analyses (qPCR and RNAseq), serum to measure circulating FGF21 levels and DNA for genotyping the FGF21 rs838133 variant in both estimation and validation cohorts. A hepatocyte-derived cell line was exposed to...
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