Article

FGF21, a liver hormone that inhibits alcohol intake in mice, increases in human circulation after acute alcohol ingestion and sustained binge drinking at Oktoberfest

2018-02-13

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objective</h4> Excessive alcohol consumption is a leading cause of global morbidity and mortality. However, knowledge of the biological factors that influence ad libitum alcohol intake may be incomplete. Two large studies recently linked variants in the KLB locus with levels of alcohol intake in humans. KLB encodes ß-klotho, co-receptor for the liver-derived hormone fibroblast growth fac...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: da481c11-167b-59b8-81fd-a2d23302e375
DOI: 10.1101/264234

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

FGF21, a liver hormone that inhibits alcohol intake in mice, increases in human circulation after acute alcohol ingestion and sustained binge drinking at OktoberfestDOI 10.1101/264234Read

KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference.Semantic proximity Read

FGF21 deletion mildly exacerbates hepatic dysfunction in MASH diet and alcohol fed ratsSemantic proximity Read

Robust human genetic evidence supporting causal effects of FGF21 on reducing alcohol consuming behaviours.Semantic proximity Read

Robust human genetic evidence supporting causal effects of FGF21 on reducing alcohol consuming behavioursSemantic proximity Read

Fibroblast growth factor 21: update on genetics and molecular biology.Semantic proximity Read

FGF21 Is a Sugar-Induced Hormone Associated with Sweet Intake and Preference in Humans.Semantic proximity Read

The role of fibroblast growth factor 21 in the pathogenesis of liver disease: a novel predictor and therapeutic targetSemantic proximity Read

Distinct genetic signals at the FGF21 locus complicate studies of FGF21's role in diet regulation using human cohort data.Semantic proximity Read

Plasma MicroRNA Signature of Alcohol Consumption: The Rotterdam Study.Semantic proximity Read

Diet pattern determines circulating FGF21 levels while distinct FGF21 variants influence diet pattern and FGF21 levelsSemantic proximity Read

FGF21 reflects a responsive adipose tissue-liver axis in both cardiometabolic burden and following metabolic surgerySemantic proximity Read

Reversion of metabolic dysfunction-associated steatohepatitis by skeletal muscle-directed FGF21 gene therapySemantic proximity Read