Article

Characterization and contribution of RPE senescence to Age-related macular degeneration in <i>Tnfrsf10</i> knock out mice

2023-08-06

Abstract excerpt

<h4>Background</h4> Retinal pigment epithelial cells (RPE) play vital role in the pathogenesis of age-related macular degeneration (AMD). Our laboratory has shown that RPE cellular senescence contributed to the pathophysiology of experimental AMD, and SASP members are involved in this process. Recently, we presented confirmatory evidence to earlier GWAS studies that dysregulation of tumor necrosis factor receptor...

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Literature Corpus work: cbd8a047-e727-5625-88c2-629670a66bb1
DOI: 10.1101/2023.08.04.552052

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