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Article

Senescence in the pathogenesis of age-related macular degeneration

2 Jan 2020

Abstract excerpt

Age-related macular degeneration (AMD) is a complex eye disease underlined by the death of photoreceptors and degeneration of retinal pigment epithelium (RPE) and choriocapillaris (CC). The mechanism(s) responsible for massive and progressive retinal degeneration is not completely known. Senescence, a state of permanent inhibition of cell growth, may be induced by many factors important for AMD pathogenesis and...

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PMID: 31897543
DOI: 10.1007/s00018-019-03420-x

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