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The role of Aβ circRNA in Alzheimer’s disease: alternative mechanism of Aβ biogenesis from Aβ circRNA translation

2018-02-06

Abstract excerpt

Alzheimer’s disease (AD) is an age-related detrimental dementia. Amyloid beta peptides (Aβ) play a crucial role in the pathology of AD. In familial AD, Aβ is generated from the full-length amyloid precursor protein (APP) via dysregulated proteolytic processing. However, Aβ biogenesis in case of sporadic AD remains so far elusive. circRNAs are a class of transcripts, which are preferentially expressed in brain. He...

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Literature Corpus work
fe64e367-7b61-5e3d-be37-3e448904dc9b
DOI
10.1101/260968
Open publication

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The role of Aβ circRNA in Alzheimer’s disease: alternative mechanism of Aβ biogenesis from Aβ circRNA translationDOI 10.1101/260968
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