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Phenotype-Directed Precision Therapeutics: A Framework for Multi-Agonist Therapy in Obesity, MASH and Cardio-Renal-Metabolic Disorders

2026-07-03

Abstract excerpt

The rapid development of pharmacotherapy has progressed from using single GLP-1 receptor agonists, such as semaglutide, to more complex options like dual incretin agonism with GLP-1/GIP (tirzepatide) and GLP-1/glucagon co-agonism (survodutide). Other combinations include GLP-1/amylin (CagriSema) and triple agonism (retatrutide). This evolution highlights that metabolic disease is not a uniform biological condition...

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Literature Corpus work
b16678e5-dcf4-5c3c-a56d-eb6cd0f6ac23
DOI
10.20944/preprints202607.0236.v1
Open publication

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Phenotype-Directed Precision Therapeutics: A Framework for Multi-Agonist Therapy in Obesity, MASH and Cardio-Renal-Metabolic DisordersDOI 10.20944/preprints202607.0236.v1
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