Article

Integrative multiomics analysis and CRISPR screening identify functional noncanonical translation loci in the mouse immune system

2026-02-24

Abstract excerpt

Ribosome profiling has revealed thousands of noncanonical translation events across mammalian genomes, yet functional characterization has overwhelmingly focused on proliferative fitness in cancer cell lines. Here, we present a comprehensive survey of noncanonical translation in the mouse immune system and its functional consequences in macrophages. By performing a unified Ribo-seq meta-analysis across 20 public m...

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Identifiers and source

Literature Corpus work: 61a9d616-7806-5302-afc7-1bdc46b5865c
DOI: 10.64898/2026.02.23.707583

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