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Article

Aberrant TET1 Methylation Closely Associated with CpG Island Methylator Phenotype in Colorectal Cancer.

Cancer prevention research (Philadelphia, Pa.) - 1 Aug 2015

Ichimura Norihisa, Shinjo Keiko, An Byonggu, Shimizu Yasuhiro, Yamao Kenji, Ohka Fumiharu, Katsushima Keisuke, Hatanaka Akira, Tojo Masayuki, Yamamoto Eiichiro, Suzuki Hiromu, Ueda Minoru, Kondo Yutaka

Abstract excerpt

Inactivation of methylcytosine dioxygenase, ten-eleven translocation (TET) is known to be associated with aberrant DNA methylation in cancers. Tumors with a CpG island methylator phenotype (CIMP), a distinct subgroup with extensive DNA methylation, show characteristic features in the case of colorectal cancer. The relationship between TET inactivation and CIMP in colorectal cancers is not well understood. The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26063725
DOI: 10.1158/1940-6207.CAPR-14-0306

Genes

TET1
BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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