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A human fetal lung cell atlas uncovers proximal-distal gradients of differentiation and key regulators of epithelial fates

1 Dec 2022

Abstract excerpt

We present a multiomic cell atlas of human lung development that combines single-cell RNA and ATAC sequencing, high-throughput spatial transcriptomics, and single-cell imaging. Coupling single-cell methods with spatial analysis has allowed a comprehensive cellular survey of the epithelial, mesenchymal, endothelial, and erythrocyte/leukocyte compartments from 5-22 post-conception weeks. We identify previously...

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PMID: 36493756
DOI: 10.1016/j.cell.2022.11.005

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