Back to search

Article

A human fetal lung cell atlas uncovers proximal-distal gradients of differentiation and key regulators of epithelial fates

2022-01-11

Abstract excerpt

We present a multiomic cell atlas of human lung development that combines single cell RNA and ATAC sequencing, high throughput spatial transcriptomics and single cell imaging. Coupling single cell methods with spatial analysis has allowed a comprehensive cellular survey of the epithelial, mesenchymal, endothelial and erythrocyte/leukocyte compartments from 5-22 post conception weeks. We identify new cell states in...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
49f5ac84-14e5-5abb-915e-21fe2b3b4943
DOI
10.1101/2022.01.11.474933
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A human fetal lung cell atlas uncovers proximal-distal gradients of differentiation and key regulators of epithelial fatesDOI 10.1101/2022.01.11.474933
A human fetal lung cell atlas uncovers proximal-distal gradients of differentiation and key regulators of epithelial fatesSemantic proximity
A single-cell atlas of human fetal lung development between 14 and 19 weeks of gestationSemantic proximity
Early human fetal lung atlas reveals the temporal dynamics of epithelial cell plasticitySemantic proximity
Early human fetal lung atlas reveals the temporal dynamics of epithelial cell plasticitySemantic proximity
Developmental origins of cell heterogeneity in the human lungSemantic proximity
A molecular cell atlas of the human lung from single cell RNA sequencingSemantic proximity
Early human fetal lung atlas reveals the temporal dynamics of epithelial cell plasticitySemantic proximity
A topographic atlas defines developmental origins of cell heterogeneity in the human embryonic lungSemantic proximity
Single-cell RNA sequencing reveals the developmental program underlying proximal–distal patterning of the human lung at the embryonic stageSemantic proximity
An integrated single-cell atlas of human lung across the lifespanSemantic proximity
Chromatin and gene-regulatory dynamics of human pulmogenesis by single cell multiomic sequencingSemantic proximity
An integrated single cell and spatial omics atlas of human prenatal developmentSemantic proximity
Select a neighboring publication to make it the new centre.