Article

MitoDelta: identifying mitochondrial DNA deletions at cell-type resolution from single-cell RNA sequencing data

2025-06-14

Abstract excerpt

<h4>Background</h4> Deletion variants in mitochondrial DNA (mtDNA) are associated with various diseases, such as mitochondrial disorders and neurodegenerative diseases. Traditionally, mtDNA deletions have been studied using bulk DNA sequencing, but bulk methods average signals across cells, thereby masking the cell-type-specific mutational landscapes. Resolving mtDNA deletions at single-cell resolution is benefic...

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Literature Corpus work: 0d0e104e-871d-5bb6-849d-daaf084b2a5d
DOI: 10.1101/2025.06.10.658806

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