Article

Dietary lipids, not ketone body metabolites, influence intestinal tumorigenesis in a ketogenic diet

2025-06-07

Abstract excerpt

Diet composition shapes tissue function and disease risk by modulating nutrient availability, metabolic state, and cellular dynamics. In the gastrointestinal tract, obesogenic high-fat diets enhance intestinal stem cell activity and tumorigenesis. However, the impact of ketogenic diets (KD), which contain even higher lipid content but induce ketogenesis, remains poorly understood. This is particularly relevant for...

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Literature Corpus work: cb32578d-02ff-5574-9635-25d1aa78979c
DOI: 10.1101/2025.06.06.658169

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