Prevention of Dietary-Fat-Fueled Ketogenesis Attenuates BRAF V600E Tumor Growth.

doi:10.1016/j.cmet.2016.12.010

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Article

Prevention of Dietary-Fat-Fueled Ketogenesis Attenuates BRAF V600E Tumor Growth.

Cell metabolism - 7 Feb 2017

Xia Siyuan, Lin Ruiting, Jin Lingtao, Zhao Liang, Kang Hee-Bum, Pan Yaozhu, Liu Shuangping, Qian Guoqing, Qian Zhiyu, Konstantakou Evmorfia, Zhang Baotong, Dong Jin-Tang, Chung Young Rock, Abdel-Wahab Omar, Merghoub Taha, Zhou Lu, Kudchadkar Ragini R, Lawson David H, Khoury Hanna J, Khuri Fadlo R, Boise Lawrence H, Lonial Sagar, Lee Benjamin H, Pollack Brian P, Arbiser Jack L, Fan Jun, Lei Qun-Ying, Chen Jing

Abstract excerpt

Lifestyle factors, including diet, play an important role in the survival of cancer patients. However, the molecular mechanisms underlying pathogenic links between diet and particular oncogenic mutations in human cancers remain unclear. We recently reported that the ketone body acetoacetate selectively enhances BRAF V600E mutant-dependent MEK1 activation in human cancers. Here we show that a high-fat ketogenic...

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PMID: 28089569
DOI: 10.1016/j.cmet.2016.12.010
PMCID: PMC5299059

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BRAF

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